Study of effect of temperature on the separation process of triadimefon enantiomers on coated cellulose 4-based chiral stationary phase in hight-performance liquid chromatograpy

The goal of our research was to study of effect of temperature on the separation process of triadimefon enantiomers on coated cellulose tris (4-chloro-3-methylphenylcarbamate)-based chiral stationary phase in hight-performance liquid chromatograpy (HPLC) with mobile phases such as methanol, acetonitrile and hexane-2propanol. Enantiomerization is a process describing the reversible conversion of one enantiomer into the other on a microscopic level. Temperature dependence of rate constants of enantiomerization can be conveniently studied chromatographically using peak shape analysis. a peak from analyisis describes the elution profiles of interconverting enantiomers during their resolution on a chiral stationary phase in a HPLC column. Triadimefon is a systemic fungicide in the triazole family of chemicals, which is used in agriculture to control various fungal diseases. As a seed threatment it is used on a barly, corn, cotton etc. Non-food uses include pine seedlings, Christmas trees, landscaping.