Effects of quercetin conjugated magnetic nanoparticles over the hippocampus neuronal activity

Author: Teimurazi Gochitashvili
Keywords: Hippocampus, neuronal activity, magnetic nanoparticles, quercetin
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Hippocampus has been a subject of scientific enquiry for a long time. It has become even more popular after providing it's role in long-term memory. There had been many scientific discoveries, concerning it's role in neurodegenerative disorder development. In particular Alzheimer's disease and epilepsy. Hence, hippocampus is a subject of scientific investigation for finding therapeutics. On the other hand, lately, plant based antioxidants have gained interest for treating such disorders. With this in mind, hippocampus is vulnerable towards oxidative stress, while quercetin is identified as one of the best antioxidant flavonoid. Quercetin's effectivity is well established in curing various diseases. Namely, it is a good anti inflammatory, anticancer drug. Sadly, quercetin is characterized to be having a low bioavailability and instability. Hence, for identifying it's effects on central neural system, we've used one of the most acknowledged technology in biomedicine - iron magnetic nanoparticles(IONPs). Magnetic nanoparticles(MNPs) are diverse, especially in their shape, size and nature. Hence, it is possible to utilize their specific characteristics for specific results. MNPs are especially important, having in account that it's feasible to control it's movement using external static magnetic field(ESMF). Thus, we've exploited IONP conjugated quercetin for performing tissue specific delivery using ESMF. Markedly, for qualifying quercetin and quercetin-conjugated magnetic nanoparticle(QMNPs) effects on hippocampus neuronal activity. Two groups of laboratory rats were used for experimenting. We've investigated quercetin(25mg/kg) influence over baseline of CA1 region of hippocampus. In addition, we've established QMNP impact over neural activity of hippocampus while projecting ESMF over temporal lobe. For analyzing the results we've used Lab Chart 30/4 system and PRISM. Results have shown that quercetin independently does not induce effects in neuronal activity of CA1 region of hippocampus. Following this, ESMF driven QMNPs decreases amplitudes and induces increase in response discharges.