On our way to sub-second separations of enantiomers in high-performance liquid chromatography

Author: Salome Pantsulaia
Co-authors: Nana Khundadze, Khatia Targamadze, Rusudan Kakava
Keywords: Fast separations, chiral sulfoxides, enantiomers, superficially porous silica, fully porous silica, high performance liquid chromatography
Annotation:

Enantioseparation of chiral sulfoxides on totally porous silica coated with polysaccharide-based chiral selectors in ultrafast-high performance liquid chromatography. The major goal of our study was to separate enantiomers of chiral sulfoxides on totaly porous silica particles coated with polysaccharide-based chiral selectors. Nowdays chiral sulfoxides attract a great attention of chemists since these materials are widely used as pharmaceuticals, agrochemicals, ligands for catalysts, as synthetic intermediates, etc. The main goal of our experiment was to separate enantiomers of novel chiral sulfoxides with the shortest possible analysis time and high efficiency. We used some new chiral columns and achieved baseline separation of novel sulfoxide enantiomers with the analysis time below 1 minute.