Study of temperature influence for oxazepam on chiral stationary phases cellulose (3,5-dimethylphenyl carbate) and (3,5-dichlorophenyl carbamates) on chromatographic columns in liquid chromatography

Author: RUSUDAN SAKEVARASHVILI
Co-authors: giorgi kobidze,aluda chelidze,gizo dolidze
Keywords: chiral substances, enantiomers, liquid chromatography, mobphaseile, gas chromatography, capillary electrophoresis, oxazepam, cellulose
Annotation:

In this work the dependence of retention and enantioselectivity on temperature was studied for oxazepam on chiral stationary phases made by attachment of cellulose tris(3,5-dimethylphenyl corbate) and cellulose tris(3,5-dichlorophenyl carbamate)s onto silica in high-performance liquid chromatography. The purpose was to study the influence of temperature on the enantioseparation process and determination of kinetic parameters. Based on the obtained results the rate constants and activation energy of enantiomerization process were determined.

Lecture files:

ტემპერატურის გავლენის შესწავლა ოქსაზეპამის ენანტიომერების დაყოფაზე ცელულოზა ტრის(3,5-დიქლორფენილკარბამატის)და (3,5-დიმეთილფენილკარბამატის)ქრომატოგრაფიულ სვეტებზე სითხურ ქრომატოგრაფიაში [ka]