Synthesis of chiral sulfoxides and study of enantioseparation in high performance liquid chromatography

Summary The main goal of the master thesis was the synthesis of new sulfoxide and study of it’s enantioseparation using polysaccharide-based chiral selectors. In the frame of the current thesis pharmaceutical drug compound – sulconazole was oxidized to sulconazole sulfoxide using 3-chloroperbenzoicc acid at 00 C. Reaction product was purified using flash chromatography. Final product was identified and characterized using UV-VIS, IR and NMR spectroscopic methods. In order to establish relationship between structure of chiral selector and enantioselectivity, enantiomeric separation of synthesized compound was studied using high-performance liquid chromatographic method. Methanol and acetonitrile were used as mobile phases. As stationary phases the following columns were utilized: Amylose-1, Amylose-2, Celulose-2, Celulose-3, Celulose-4, SP1 , iSP5, SP10, iSP11 .

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